塞纳河上，巴黎岸边，那艘停靠了21年的书船突然起航了。
书船主人佩尔杜先生有口皆碑，他独自经营着这家叫“水上文学药房”的书店，自称“文学药剂师”。他与人为善，又个性执拗，会通过眼睛、耳朵和直觉，辨别出每一个灵魂所欠缺的东西，再把自己视为“解药”的书卖给对方。他以书为药， 相信唯有文学才能治愈人心。
而他自己却深陷隐痛，围困其中。
21年前，佩尔杜的挚爱曼侬忽然不告而别，留下一封信。他逃避着，不敢拆开它。
21年后，佩尔杜意外得知曼侬的离去另有隐情，那不是一封分手信，而是一封求助信！
他当即决定驾船南下，从巴黎前往曼侬的故乡普罗旺斯。
与他意外同行的，是一位失去创作灵感的畅销书作家、一位追寻爱人多年的意大利厨师，还有两只博览群书的猫。
河流上的美景、偏远的小镇书城、乡村欢乐的舞会、沿途拜访的作家……这场延滞的冒险以及那个迟到已久的真相，究竟会彻底击垮佩尔杜先生，还是成为抚平他伤口的解药呢？
Monsieur Perdu calls himself a literary apothecary. From his floating bookstore in a barge on the Seine, he prescribes novels for the hardships of life. Using his intuitive feel for the exact book a reader needs, Perdu mends broken hearts and souls. The only person he can’t seem to heal through literature is himself; he’s still haunted by heartbreak after his great love disappeared. She left him with only a letter, which he has never opened.
After Perdu is finally tempted to read the letter, he hauls anchor and departs on a mission to the south of France, hoping to make peace with his loss and discover the end of the story. Joined by a bestselling but blocked author and a lovelorn Italian chef, Perdu travels along the country’s rivers, dispensing his wisdom and his books, showing that the literary world can take the human soul on a journey to heal itself.
Internationally bestselling and filled with warmth and adventure, The Little Paris Bookshop is a love letter to books, meant for anyone who believes in the power of stories to shape people’s lives.
