警方卧底探员弗莱德常年混迹在毒瘾患者中，希望通过各种毒品交易顺藤摸瓜抓出背后的大毒枭。耳濡目染间，他自己的毒瘾愈发严重，毒品开始损害他的大脑认知系统。他慢慢分不清虚幻和现实。
不祥的幻觉，离奇的车祸，难解的谜题，随着弗莱德身边涌出越来越多的怪事，危险似乎也在步步紧逼，究竟是敌人发现了他的真实身份，还是毒品已经彻底击垮了他的神经。
无尽的药丸，神秘的蓝花，弗雷德在毒品与真相之间，究竟步向何方？
Substance D is not known as Death for nothing. It is the most toxic drug ever to find its way on to the streets of LA. It destroys the links between the brain’s two hemispheres, causing, first, disorientation and then complete and irreversible brain damage.
The undercover narcotics agent who calls himself Bob Arctor is desperate to discover the ultimate source of supply. But to find any kind of lead he has to pose as a user and, inevitably, without realising what is happening, Arctor is soon as addicted as the junkies he works among…
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