20世纪初，现代医学和技术的高歌猛进曾让人类无比自信地以为自己已经战胜了流行病。然而我们错了。
潜藏在自然界黑暗角落里的神秘病菌突然现身人类的大都市，导致成千上万人感染甚至死去。从导致上千万人丧生的大流感，到突然降临“天使之城”洛杉矶的鼠疫；从导致美国贵妇人神秘死亡的鹦鹉热，到感 染后会出现大出血的埃博拉，每次疫情的暴发都令人猝不及防，打击着人类的自信。
病菌的突然到来一时间会导致社会恐慌，甚至会引发一连串的社会和政治危机。但也有人迎难而上，去寻找病原体的真实面目。
通过抽丝剥茧的探案式写法，作者为我们揭示了“微生物猎手”们是如何找到病原体和传播途径的，讲述了他们经历了怎样的挫折，遇到过怎样的阻碍，不同的“猎手”之间产生过怎样的分歧，最后又是如何取得成功的，以及尚有哪些谜题至今仍未被解开。
全球化和城市化的发展使得人类文明空前进步，但也正是全球化和城市化导致了病菌的全球扩散。短短几个小时，病菌就可能乘着国际航班跨越大洲和大洋，来到我们的身边，并在短短数天内，感染城市里成千上万的人。
我们人类必将与病菌继续共存下去。在可以预见的未来，全球性的流行病还将会不时地出现。如果我们可以不断反思过往的教训，在研究病菌的同时，不断改善导致瘟疫暴发的社会和环境条件，不再狂妄自大，也许，我们在应对下一场全球性流行病时能取得比现在更好的成绩。
Ever since the 1918 Spanish influenza pandemic, scientists have dreamed of preventing catastrophic outbreaks of infectious disease. Yet despite a century of medical progress, viral and bacterial disasters continue to take us by surprise, inciting panic and dominating news cycles. From the Spanish flu to the 1924 outbreak of pneumonic plague in Los Angeles to the 1930 “parrot fever” pandemic, through the more recent SARS, Ebola, and Zika epidemics, the last one hundred years have been marked by a succession of unanticipated pandemic alarms.
In The Pandemic Century, a lively account of scares both infamous and less known, Mark Honigsbaum combines reportage with the history of science and medical sociology to artfully reconstruct epidemiological mysteries and the ecology of infectious diseases. We meet dedicated disease detectives, obstructive or incompetent public health officials, and brilliant scientists often blinded by their own knowledge of bacteria and viruses. Like man-eating sharks, predatory pathogens are always present in nature, waiting to strike; when one is seemingly vanquished, others appear in its place. These pandemics remind us of the limits of scientific knowledge, as well as the role that human behavior and technologies play in the emergence and spread of microbial diseases.
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