优雅的守卫者 – An Elegant Defense: The Extraordinary New Science of the Immune System: A Tale in Four Lives by Matt Richtel

免疫系统是人体必不可少的防御系统，它守护着我们对抗疾病，治愈伤口，维持秩序和平衡。经过几千年的发展，它已经过不断磨练，以面对几乎无限的威胁。然而，尽管免疫系统是如此复杂精妙，但它依旧容易因疲劳、压力、营养不良甚至过度卫生等因素而受到损害。它是一种脆弱而奇迹的武器。

作为一位杰出的记者、作家，普利策奖得主马特·里克特以扎实的材料和动人的笔触，为我们讲述了属于科学的侦探故事。从黑死病到20世纪的疫苗和抗生素突破，再到革新性免疫学研究的实验室，这也许是我们这个时代最特殊，最重要的医学故事。与此同时，这些故事也是在你我身上每日上演的希望、勇气与爱的故事。

A magnificently reported and soulfully crafted exploration of the human immune system–the key to health and wellness, life and death. An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.

A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel’s An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.

The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.

For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.

Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.

Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

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